hrp0084p2-192 | Adrenals | ESPE2015

Baseline Adrenal Function by Measurement of Long-term Cortisol Levels in Scalp Hair of Asthmatic Children Using Inhaled Corticosteroids Equals Healthy Controls

Smit Maria , van Leer Ed , Noppe Gerard , de Rijke Yolanda , Hoekx Jurriaan , van den Akker Erica

Background: Inhalation corticosteroids (ICS) as treatment for asthma can interfere with the hypothalamic-pituitary-adrenal axis and could lead to hypocortisolism. The frequency of this systemic side effect and the correlation to ICS usage is still unclear. Given that the cortisol excretion is pulsatile and determined by acute stress and circadian rhythms, the usefulness of tests based on momentary measures, such as saliva or serum are therefore limited. Cortisol levels measure...